cell differentiation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1124	Neoeriocitrin		AChE
	Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.		AChE
TP1328	TB500		Others
	TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4.		Others
T22814	GSA-10		Hedgehog/Smoothened
	Smoothened (Smo) receptor agonist		Hedgehog/Smoothened
T19676	Tributyrin	NSC661583,NSC 661583,NSC-661583	Apoptosis
	Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracell...		Apoptosis
T28036	MI-2-2	MI22,MI 2 2	Histone Methyltransferase
	MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.		Histone Methyltransferase
T38562	AKN-028		FLT
	AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.		FLT
T11882	Pulrodemstat benzenesulfonate	LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate	Histone Demethylase
	Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.		Histone Demethylase
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
T2051	SKLB4771	FLT3-IN-1,FLT3-IN-1	FLT
	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.		FLT
T13502	3-Oxo-5β-cholanoic acid	Dehydrolithocholic acid	ROR
	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM)...		ROR
T6711	Tyrphostin AG1296	Tyrphostin AG 1296,AG 1296	Apoptosis , FGFR , FLT , PDGFR , c-Kit
	Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.		Apoptosis , FGFR , FLT , PDGFR , c-Kit
T2514	Linifanib	ABT-869,RG3635,AL-39324	Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...
T22644	C2 Ceramide	Ceramide	Others
	A potent modulator of cell proliferation and differentiation.		Others
T10886	Crocetine dimethyl ester	Dimethylcrocetin	Antioxidant
	Crocetine dimethyl ester (Dimethylcrocetin) is a saffronin derivative with antioxidant activity, inhibition of AChE activity, and inhibition of cell growth and differentiation.		Antioxidant
T22789	FPR A14		Others
	FPR A14 is an agonist of formyl peptide receptor (FPR) and induces cell differentiation.		Others
T0421	I-Inositol	Inositol,myo-Inositol,meso-Inositol	Endogenous Metabolite
	i-Inositol (myo-Inositol) is a intracellular phosphate compound, involved in cell signaling and may stimulate tumor cell differentiation.		Endogenous Metabolite
TQ0221	Rufloxacin hydrochloride	MF-934 hydrochloride	Antibacterial
	Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial and inhibits topoisomerase. Rufloxacin hydrochloride inhibits B-cell differentiation in human mononuclear cells.		Antibacterial
T2247	KenPaullone	9-Bromopaullone,NSC-664704	GSK-3 , CDK
	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...		GSK-3 , CDK
T2157	M344	MS 344,Histone Deacetylase Inhibitor III	HDAC
	M344 (Histone Deacetylase Inhibitor III) is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.		HDAC
T11511	Guanosine-5'-triphosphate disodium salt	5'-GTP disodium salt	Others , Endogenous Metabolite
	Guanosine-5'-triphosphate disodium salt (5'-GTP disodium salt) is an enhancer of myogenic cell differentiation and an energy source for translation and other important cellular processes.		Others , Endogenous Metabolite